Vilhelm A Bohr Selected Research

Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson)

1/2020	Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase.
12/2017	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.
1/2016	RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.
7/2013	The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions.
5/2013	Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
1/2012	RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.
11/2010	Human RecQL4 helicase plays critical roles in prostate carcinogenesis.
6/2010	The involvement of human RECQL4 in DNA double-strand break repair.
9/2009	Direct and indirect roles of RECQL4 in modulating base excision repair capacity.

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Vilhelm A Bohr Research Topics

Disease

57	Werner Syndrome (Werner's Syndrome) 11/2019 - 04/2002
37	Neoplasms (Cancer) 12/2020 - 03/2002
34	Premature Aging 12/2020 - 05/2002
32	Genomic Instability 01/2021 - 04/2002
31	Cockayne Syndrome (Syndrome, Cockayne) 01/2021 - 02/2002
18	Mitochondrial Diseases (Mitochondrial Disease) 12/2020 - 08/2009
15	Alzheimer Disease (Alzheimer's Disease) 11/2021 - 01/2007
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2008
9	Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson) 01/2020 - 09/2009
9	Bloom Syndrome 05/2013 - 06/2002
6	Inborn Genetic Diseases (Disease, Hereditary) 11/2014 - 02/2003
5	Cognitive Dysfunction 01/2022 - 01/2007
5	Inflammation (Inflammations) 12/2021 - 01/2013
4	Bites and Stings (Sting) 12/2021 - 01/2021
4	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2020 - 08/2010
4	Ischemic Stroke 01/2019 - 08/2011
3	Hypersensitivity (Allergy) 01/2021 - 12/2003
3	Nervous System Diseases (Neurological Disorders) 12/2016 - 04/2012
3	Breast Neoplasms (Breast Cancer) 03/2016 - 03/2002
3	Chromosomal Instability (Chromosome Stability) 05/2013 - 06/2006
3	Carcinogenesis 12/2010 - 11/2003
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 07/2011
2	Atrophy 11/2017 - 09/2015
2	Neuroblastoma 11/2016 - 05/2011
2	Epilepsy (Aura) 01/2016 - 08/2011
2	Rare Diseases (Rare Disease) 01/2016 - 12/2004
2	Insulin Resistance 01/2013 - 01/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2011 - 07/2011
2	Osteosarcoma (Osteogenic Sarcoma) 03/2011 - 10/2006
2	Lung Neoplasms (Lung Cancer) 12/2010 - 06/2005
2	Nijmegen Breakage Syndrome 02/2005 - 05/2004
1	Tauopathies 01/2020
1	Hearing Loss (Hearing Impairment) 01/2020

Drug/Important Bio-Agent (IBA)

94	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
46	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 03/2002
34	RecQ HelicasesIBA 01/2017 - 08/2002
13	Mitochondrial DNA (mtDNA)IBA 12/2020 - 10/2002
11	Exonucleases (3' 5' Exonuclease)IBA 09/2012 - 08/2002
8	DNA Glycosylases (DNA Glycosylase)IBA 01/2021 - 01/2005
8	8-hydroxyguanineIBA 07/2015 - 02/2002
7	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2019 - 12/2003
6	DNA HelicasesIBA 01/2020 - 08/2012
5	ChromatinIBA 01/2020 - 03/2008
5	A-Form DNA (A-DNA)IBA 01/2018 - 06/2006
4	NAD (NADH)IBA 01/2020 - 11/2014
4	NucleotidesIBA 01/2017 - 05/2014
4	EnzymesIBA 02/2015 - 07/2008
3	IgA receptor (protein B)IBA 01/2021 - 01/2007
3	Amyloid beta-PeptidesIBA 01/2021 - 01/2017
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2015
3	InterferonsIBA 01/2021 - 01/2021
3	Biological ProductsIBA 01/2020 - 06/2017
3	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 02/2017 - 09/2012
3	Adenosine Triphosphate (ATP)IBA 01/2017 - 04/2004
3	Deoxyribonuclease (Pyrimidine Dimer)IBA 07/2015 - 06/2010
3	Adenosine Triphosphatases (ATPase)IBA 06/2013 - 02/2002
2	Pharmaceutical PreparationsIBA 11/2021 - 01/2013
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021 - 09/2003
2	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2021 - 01/2021
2	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2019 - 05/2004
2	Sirtuin 3IBA 01/2018 - 01/2016
2	Nucleic AcidsIBA 10/2017 - 01/2007
2	B-Form DNA (B-DNA)IBA 11/2016 - 03/2011
2	CamptothecinIBA 03/2016 - 06/2006
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 03/2016 - 12/2008
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 03/2016 - 03/2007
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2016 - 09/2012
2	Messenger RNA (mRNA)IBA 01/2016 - 06/2005
2	SirtuinsIBA 01/2016 - 01/2016
2	DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)IBA 10/2015 - 01/2007
2	LipidsIBA 09/2015 - 01/2013
2	X-ray Repair Cross Complementing Protein 1IBA 07/2015 - 08/2010
2	thymine glycolIBA 07/2015 - 03/2002
2	EndonucleasesIBA 07/2015 - 03/2004
2	Sirtuin 1IBA 11/2014 - 09/2014
2	Flap EndonucleasesIBA 04/2012 - 03/2004
2	Nuclear Proteins (Protein, Nuclear)IBA 08/2011 - 12/2004
2	Bloom syndrome proteinIBA 07/2010 - 03/2004
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2007 - 09/2003
2	DNA Polymerase beta (DNA Polymerase IV)IBA 01/2006 - 06/2003
2	8-hydroxyadenineIBA 04/2003 - 08/2002
1	SynucleinsIBA 01/2022
1	DNA Repair EnzymesIBA 01/2022
1	Apolipoproteins E (ApoE)IBA 11/2021
1	Cisplatin (Platino)FDA LinkGeneric 01/2021
1	Alkylating AgentsIBA 01/2021
1	Methyl MethanesulfonateIBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	NucleolinIBA 01/2020
1	tau Proteins (tau Protein)IBA 01/2020
1	nicotinamide-beta-ribosideIBA 01/2020
1	Lamin Type A (Lamin A)IBA 12/2019
1	Peptides (Polypeptides)IBA 01/2019
1	actinoninIBA 01/2019
1	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneIBA 01/2019
1	HeterochromatinIBA 01/2019
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2019

Therapy/Procedure

5	Therapeutics 10/2019 - 12/2008
2	Lasers (Laser) 01/2017 - 01/2013
1	Traditional Medicine (Folk Remedies) 01/2019